Roger Lefort

I am a Principal Investigator at Columbia University Irving Medical Center with a background in Molecular Biology and Chemistry. I have 10+ years of experience studying the molecular mechanisms of neurodegenerative diseases, such as Alzheimer’s and Huntington disease, with a specific focus on synaptic dysfunction.

Using a combination of genetics, systems biology, molecular biology, and animal models (mouse and drosophila) my lab has identified several signaling pathways and molecules leading to this imbalance in neurons and glial cells, including APP, Caspase-2, EphA1, and Ube3A. We are actively developing novel tools and models to validate their involvement and to investigate their potential as therapeutic targets.