Consuelo Borras

Positions, recognitions, and awards
Full professor of the Department of Physiology in the Faculty of Medicine at the University of Valencia. Co-director of the cross-cutting program Aging and associated diseases and member of the Innovation Committee of the Institute of Health Research INCLIVA.
Recognized with international and national prizes: Young Investigator Award (2004, Society for Free Radical Research International), Catherine Pasquier Award (2009, Society for Free Radical Research Europe), the García Blanco Medal Prize (2005, Centro de Investigación Príncipe Felipe (CIPF) and Universitat de València) and the V Basic Research Prize (2010, FIHCUV). Selected as one of the 25 Persons in the world with an outstanding idea in the field of aging by the “Science for Life Extension” Foundation.
Research production
3 six-year research periods (2012-2017), 13 theses, 5 international, and one with special recognition. 5 ongoing theses. Total citations: 10442, 27 articles with more than 100 citations. Citations/year (last 5 years): 444. H index 50. I10 index 87. 113 articles in journals with impact index registered in the JCR of the ISI web, 73 in Q1, 51 as first/corresponding author (Scopus). She has also published 10 book chapters (6 international and 4 national). She has also made 3 research contracts with private companies (NISA Foundation, FiPharma, and Asea Global).
Pre-doctoral stay in London at The Centre for Cardiovascular Biology and Medicine in Kings College, London, with Prof Giovanni E. Mann, studying the protective effect of soya administration on antioxidant enzyme levels and cardiovascular function (FASEB J. 2005). As a postdoc, she stayed at the Centro Nacional de Investigaciones Oncológicas in Madrid, with Dr. María A. Blasco and Dr. Manuel Serrano, where she studied genes related to successful aging such as p53 and telomerase (Nature. 2007; Cell. 2008). More recently, she has stayed with Dr. Ana Mª Cuervo studying autophagy and aging at the Einstein College of Medicine (New York, 2019). Ponent in 87 congresses (33 international)
After twenty years of studying the molecular basis of aging and possible interventions to achieve successful aging, she has found that oxidative stress is related to sex differences in longevity (a. (FRBM, 2003; Aging Cell, 2005; ARS, 2014; Oxid Med Cell Longev. 2019; Mech Ageing Dev. 2021; Oxid Med Cell Longev. 2021 and Sci Adv. 2021). She has also studied the centenarians’ distinct genetic and epigenetic characteristics (Aging Cell. 2014; Sci Rep. 2012, Aging 2016; J Gerontol A Biol Sci Med Sci., 2017, 2019, 2022 (2); Mech Ageing Dev. 2017; Redox Biol 2019 and Free Radic Biol Med. 2019, 2021).
10 Selected publications
1. Inglés M, Belenguer-Varea A, Serna E, Mas-Bargues C, Tarazona-Santabalbina FJ, Borrás C, Vina J. Functional transcriptomic analysis of centenarians’ offspring reveals a specific genetic footprint that may explain that they are less frail than age-matched non-centenarians’ offspring. J Gerontol A Biol Sci Med Sci. 2022 May 28:glac119. doi: 10.1093/gerona/glac119. Online ahead of print.
2. Duro-Castano A, Borrás C, Herranz-Pérez V, Blanco-Gandía MC, Conejos-Sánchez I, Armiñán A, Mas-Bargues C, Inglés M, Miñarro J, Rodríguez-Arias M, García-Verdugo JM, Viña J, Vicent MJ. Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates. Sci Adv. 2021 Mar 26;7(13):eabf9180. doi: 10.1126/sciadv.abf9180. Print 2021 Mar.
3. Inglés M, Mas-Bargues C, Berna-Erro A, Matheu A, Sanchís P, Avellana JA, Borrás C, Viña J. Centenarians Overexpress Pluripotency-Related Genes.
J Gerontol A Biol Sci Med Sci. 2019 Aug 16;74(9):1391-1395. doi: 10.1093/gerona/gly168.
4. Mas-Bargues C, Viña-Almunia J, Inglés M, Sanz-Ros J, Gambini J, Ibáñez-Cabellos JS, García-Giménez JL, Viña J, Borrás C. Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. Redox Biol. 2017 Aug;12:690-698. doi: 10.1016/j.redox.2017.04.002. Epub 2017 Apr 7.
5. Inglés M, Gambini J, Mas-Bargues C, García-García FJ, Viña J, Borrás C.
Brain-Derived Neurotrophic Factor as a Marker of Cognitive Frailty. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):450-451. doi: 10.1093/gerona/glw145.
6. El Alami M, Viña-Almunia J, Gambini J, Mas-Bargues C, Siow RC, Peñarrocha M, Mann GE, Borrás C, Viña J. Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2.
Stem Cell Reports. 2014 Oct 14;3(4):566-73. doi: 10.1016/j.stemcr.2014.08.002. Epub 2014 Sep 18.
7. López-Grueso R, Gambini J, Abdelaziz KM, Monleón D, Díaz A, El Alami M, Bonet-Costa V, Borrás C, Viña J. Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy.
Antioxid Redox Signal. 2014 Jan 10;20(2):236-46. doi: 10.1089/ars.2012.5112. Epub 2013 Jul 20.
8. Viña J, Borras C, Gomez-Cabrera MC. Overweight, obesity, and all-cause mortality. JAMA. 2013 Apr 24;309(16):1679. doi: 10.1001/jama.2013.3080.
9. Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008 Nov 14;135(4):609-22. doi: 10.1016/j.cell.2008.09.034.
10. Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007 Jul 19;448(7151):375-9. doi: 10.1038/nature05949.

Funding
Prof. Borras has managed 10 research projects as a PI, one from the European Union (ref. JPI HDHL INTIMIC-085, 2017-2022), and 2 from the Ministry of Science and Innovation (PCIN-2017-117 and PID2020-113839RB-I00) 4 from the regional government, and 4 intramural projects. She is the PI of research equipment (Seahorse and IVIS) obtained with FEDER funds. She also received funds to organize as PI the 2014 SFRR-e Summer School.
Editor and reviewing appointments
Specialty chief editor of Frontiers in Aging (Molecular mechanisms of aging). Associate editor of Oxidative Medicine and Longevity (Q1), Antioxidants (Q1), International Journal of Molecular Sciences (Q1), Plos One, Sexes, Nutrition, And Food Science. Reviewer for more than 50 journals indexed on the ISI web and reviewer of projects for national and international research agencies (ANEP, Agencia Nacional De Colombia, German-Israeli Foundation, Poland National Science Center, Czech Science Foundation or BBSRC, UK)