• method of inducing human hepatic differentiation from human definitive endoderm cells or pluripotent or multipotent cells to produce a population of human hepatoblast-like cells or hepatocyte-like cells, by using human laminin
• method of inducing human hepatic differentiation from human pluripotent or multipotent cells to produce a population of human definitive endoderm cells , by using human laminin

• Therapeutic applications of specific cells for the treatment of hepatic disorders requiring rapid maintenance of hepatic function (including acute liver failure and acute chronic liver failure) – said cells expressing particular markers.
• Population of cells comprising said specific cells.

iMilleniumTM production platform:
• produces frozen hepatic cells from pluripotent stem cells (GStemHep).
• provides a scalable, cost-efficient solution to address cell therapy manufacturing bottlenecks at the commercial scale and throughout all the clinical trial studies.

Cryopreservation
• Large scale cells cryopreservation – Goliver Tx has developed a cryopreservation process allowing very high cell concentration per ml in a vaccine-like polymer vials opening the use of traditional pharmaceutic automatic and high-throughput vial filling system and storage in a minimal space.
• “killed PSCs” : improved biosafety (reduced risks of teratoma formation)

Ready-to-use product
• Allogeneic
• off-the-shelf product
• Biosafety (immune rejection after therapeutic efficacy in ALF)
• affordable price

Trademark