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Total reviews: 8
Level: Intermediate
Member Since: 20/02/2019

Profile Information

First name Erin
Last name Reineke
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I am an accomplished biomedical scientist with 12+ years managing projects in molecular and biochemical research that is currently a PI of an independent research laboratory. My research involves the critical interplay between metabolism, growth and cardiac function during times of stress. We are highly interested in what drives adaptive, beneficial molecular changes in cardiomyocytes and cardiac microvascular endothelial cells during cardiac stress versus the changes that lead to maladaptive remodeling and decreased cardiac function. My previous research uncovered that loss of one SRC family member, SRC-2, results in substantial gene expression remodeling in the heart that causes significant alterations in the ability of the heart to compensate for increased stress. Characterization of this model has led to our current research investigating integration of protein synthesis control downstream of hypertrophy with transcriptional responses and cardiac function during pathological heart stress. While cardiovascular disease remains a leading cause of death in the United States, the molecular understanding of what molecular components mediate coordination of the major pathways involved in the cardiac stress response are largely unknown. Gaining an understanding of what drives the molecular changes during cardiac stress and how the different stress responsive pathways communicate with each other will lead to novel, invaluable information for the eventual treatment and perhaps prevention of cardiovascular disease. We hope to be a significant force in uncovering these mechanisms.

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Name

Erin Reineke

I have professional experience in:

Genomics, Medicine, Personalised medicine, Therapeutics, cardiology, endocrinology / diabetes, molecular diagnostics

Help us confirm that you're an expert

I am an accomplished biomedical scientist with 12+ years managing projects in molecular and biochemical research that is currently a PI of an independent research laboratory. My research involves the critical interplay between metabolism, growth and cardiac function during times of stress. We are highly interested in what drives adaptive, beneficial molecular changes in cardiomyocytes and cardiac microvascular endothelial cells during cardiac stress versus the changes that lead to maladaptive remodeling and decreased cardiac function. My previous research uncovered that loss of one SRC family member, SRC-2, results in substantial gene expression remodeling in the heart that causes significant alterations in the ability of the heart to compensate for increased stress. Characterization of this model has led to our current research investigating integration of protein synthesis control downstream of hypertrophy with transcriptional responses and cardiac function during pathological heart stress. While cardiovascular disease remains a leading cause of death in the United States, the molecular understanding of what molecular components mediate coordination of the major pathways involved in the cardiac stress response are largely unknown. Gaining an understanding of what drives the molecular changes during cardiac stress and how the different stress responsive pathways communicate with each other will lead to novel, invaluable information for the eventual treatment and perhaps prevention of cardiovascular disease. We hope to be a significant force in uncovering these mechanisms.

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http://www.linkedin.com/in/erin-reineke-96986416a

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