David Moura

I’m currently a postdoctoral researcher in the Institute of Biomedicine of Sevilla, Spain. My work concerns the description of new prognostic and predictive biomarkers in sarcomas, as well as to test new therapies in this group of histologies. Besides, I’m interested in studying the role of tumour microenvironment in tumour development and in the response to therapy. Among the mains targets in my research stands HMGA1. Nowadays and regarding this protein, I’m searching for the mechanisms underlying HMGA1-associated worse prognosis in soft-tissue sarcoma, since we have preliminary data confirming worse overall survival and progression-free survival in patients with determined levels of HMGA1. Moreover, I’m currently responsible to generate a PDX platform of sarcomas in the institute of biomedicine of Sevilla. So far, we have stablish 16 PDX models of sarcoma for drug testing and cell signal pathways studies. Next step, will be the generation of 3-D models of sarcomas, from these PDX models.